[HTML][HTML] Telomeres, stem cells, senescence, and cancer

NE Sharpless, RA DePinho - The Journal of clinical …, 2004 - Am Soc Clin Investig
The Journal of clinical investigation, 2004Am Soc Clin Investig
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue
stem cells. These self-renewing cells are rendered malignant by a small number of
oncogenic mutations, and overlapping tumor suppressor mechanisms (eg, p16INK4a-Rb,
ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial
antitumor pathways, however, appear also to limit the stem cell life span, thereby
contributing to aging.
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16INK4a-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.
The Journal of Clinical Investigation