Immunopotentiating role of IFN-γ in early and late stages of type 1 CD8 effector cell-mediated tumor rejection
MJ Dobrzanski, JB Reome, RW Dutton - Clinical Immunology, 2001 - Elsevier
Type 1 cytolytic CD8 effector T cells (Tc1) characteristically secrete IFN-γ. Using an OVA-
transfected B16 melanoma lung tumor model, we show that OVA Ag-specific Tc1 cells
mediate a reduction in tumor growth that significantly prolongs survival in tumor-bearing
mice. Transfer of Tc1 cells from OT-I mice crossed to IFN-γ-KO mice showed that IFN-γ-
deficient Tc1 effector cells were less therapeutically effective than corresponding cells from
wildtype mice. Therapeutic effects were dependent, in part, on effector cell-derived IFN-γ …
transfected B16 melanoma lung tumor model, we show that OVA Ag-specific Tc1 cells
mediate a reduction in tumor growth that significantly prolongs survival in tumor-bearing
mice. Transfer of Tc1 cells from OT-I mice crossed to IFN-γ-KO mice showed that IFN-γ-
deficient Tc1 effector cells were less therapeutically effective than corresponding cells from
wildtype mice. Therapeutic effects were dependent, in part, on effector cell-derived IFN-γ …