Specificity of homograft rejection in vivo, assessed by inoculation of artificially mixed compatible and incompatible tumor cells
E Klein, G Klein - Cellular immunology, 1972 - Elsevier
The specificity of in vivo rejection across an H-2 barrier was reinvestigated by mixing a small
number of compatible tumor cells with a large number of incompatible cells and comparing
the outgrowth of the compatible minority with appropriate control groups, inoculated with
compatible cells alone, or compatible cells mixed with irradiated syngeneic cells. Eight
mouse lymphomas and nine methylcholanthrene-induced sarcomas were tested in various
combinations. There was no inhibition of the compatible minority by a 10 1–10 5-fold excess …
number of compatible tumor cells with a large number of incompatible cells and comparing
the outgrowth of the compatible minority with appropriate control groups, inoculated with
compatible cells alone, or compatible cells mixed with irradiated syngeneic cells. Eight
mouse lymphomas and nine methylcholanthrene-induced sarcomas were tested in various
combinations. There was no inhibition of the compatible minority by a 10 1–10 5-fold excess …