Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis
E Wallström, P Diener, Å Ljungdahl, M Khademi… - Journal of the …, 1996 - Elsevier
Memantine, a clinically employed drug with N-methyl-d-aspartate (NMDA) receptor
antagonistic effects, dose-dependently ameliorates neurological deficits in Lewis rat
experimental autoimmune encephalomyelitis (EAE). Interestingly, this therapeutic effect was
not due to dampened CNS inflammation, as assessed by immunohistochemical evaluation
of spinal cord tissue. Furthermore, numbers of interferon gamma (IFNγ) mRNA expressing
cells were not decreased, as assessed by in situ hybridization. Systemic immunity in terms of …
antagonistic effects, dose-dependently ameliorates neurological deficits in Lewis rat
experimental autoimmune encephalomyelitis (EAE). Interestingly, this therapeutic effect was
not due to dampened CNS inflammation, as assessed by immunohistochemical evaluation
of spinal cord tissue. Furthermore, numbers of interferon gamma (IFNγ) mRNA expressing
cells were not decreased, as assessed by in situ hybridization. Systemic immunity in terms of …