Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder
GL Hanna, JA Himle, GC Curtis, DQ Koram… - …, 1998 - Elsevier
The serotonin transporter (HTT) is a candidate gene for obsessive-compulsive disorder
(OCD) that has been associated with anxiety-related traits. The long (1) and short (s)
variants of the HTT promoter have different transcriptional efficiencies. HTT promoter
genotype and blood 5-HT concentration were examined in 70 subjects from 20 families
ascertained through children and adolescents with a DSM-III-R diagnosis of OCD. The HTT
promoter variant had a significant effect on blood 5-HT content. Subjects with the 1/1 and 1/s …
(OCD) that has been associated with anxiety-related traits. The long (1) and short (s)
variants of the HTT promoter have different transcriptional efficiencies. HTT promoter
genotype and blood 5-HT concentration were examined in 70 subjects from 20 families
ascertained through children and adolescents with a DSM-III-R diagnosis of OCD. The HTT
promoter variant had a significant effect on blood 5-HT content. Subjects with the 1/1 and 1/s …