The GPIIIa (β3 integrin) PlA polymorphism in the early development of coronary atherosclerosis
J Mikkelsson, M Perola, A Penttilä… - Atherosclerosis, 2001 - Elsevier
The GPIIIa (β3 integrin) is an integral part of two glycoprotein receptors—the GPIIb/IIIa
fibrinogen receptors in platelets and the GPV/IIIa vitronectin receptors in endothelium and
vascular smooth muscle cells (vSMC). The PlA polymorphism of the gene for GPIIIa (β3
integrin) has been suggested to play an important role in the progression of coronary artery
disease (CAD) and in coronary thrombosis. Whether the action of the PlA polymorphism is
due to differences in platelet aggregability or function of the vSMC and endothelial GPIIIa is …
fibrinogen receptors in platelets and the GPV/IIIa vitronectin receptors in endothelium and
vascular smooth muscle cells (vSMC). The PlA polymorphism of the gene for GPIIIa (β3
integrin) has been suggested to play an important role in the progression of coronary artery
disease (CAD) and in coronary thrombosis. Whether the action of the PlA polymorphism is
due to differences in platelet aggregability or function of the vSMC and endothelial GPIIIa is …