Platelet reactivity in depressed patients treated with paroxetine: preliminary findings
DL Musselman, UM Marzec… - Archives of General …, 2000 - jamanetwork.com
Background Alterations in platelet reactivity have been previously posited to underlie the
increased vulnerability of patients with depression to ischemic heart disease (IHD). The
present study sought to determine whether the increased platelet reactivity associated with
major depression is reduced after antidepressant treatment. Methods Patients diagnosed as
havingDSM-IVmajor depression (n= 15)(mean age, 37±7 years; range, 23-48 years) and 12
normal comparison subjects (mean age, 36±7; range, 23-48 years) were recruited. None of …
increased vulnerability of patients with depression to ischemic heart disease (IHD). The
present study sought to determine whether the increased platelet reactivity associated with
major depression is reduced after antidepressant treatment. Methods Patients diagnosed as
havingDSM-IVmajor depression (n= 15)(mean age, 37±7 years; range, 23-48 years) and 12
normal comparison subjects (mean age, 36±7; range, 23-48 years) were recruited. None of …