[HTML][HTML] Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling …
SH Hong, KK Park, J Magae, K Ando, TS Lee… - Journal of Biological …, 2005 - ASBMB
The expression of matrix metalloproteinases (MMPs) has been implicated in the invasion
and metastasis of cancer cells. Here we examined the effect of ascochlorin, a prenyl-phenol
anti-tumor compound from the fungus Ascochyta viciae, on the regulation of signaling
pathways that control MMP-9 expression in human renal carcinoma (Caki-1) cells.
Ascochlorin reduced the invasive activity of Caki-1 cells and inhibited phorbol 12-myristate
13-acetate-induced increases in MMP-9 expression and activity in a dose-dependent …
and metastasis of cancer cells. Here we examined the effect of ascochlorin, a prenyl-phenol
anti-tumor compound from the fungus Ascochyta viciae, on the regulation of signaling
pathways that control MMP-9 expression in human renal carcinoma (Caki-1) cells.
Ascochlorin reduced the invasive activity of Caki-1 cells and inhibited phorbol 12-myristate
13-acetate-induced increases in MMP-9 expression and activity in a dose-dependent …