This article reviews recent advances in the knowledge of the role of L-selectin, an adhesion
molecule that is expressed on the surface of circulating leucocytes, in animal and human
physiology and pathophysiology. After a brief discussion on nomenclature and structure, it
progresses through the evidence for expression and regulation of L-selectin, cell collection
and purification, physiological function and roles. The special role of knock out mice and
monoclonal antibodies in determining a role for L-selectin in inflammatory states is …