Treatment of attacks in hyperkalaemic familial periodic paralysis by inhalation of salbutamol
P Wang, T Clausen - The Lancet, 1976 - Elsevier
P Wang, T Clausen
The Lancet, 1976•ElsevierIn fifteen patients with hyperkalæmic familial periodic paralysis, inhalation of salbutamol
alleviated hyperkalæmia and paralysis precipitated by exercise or oral administration of
potassium chloride. In-vitro studies with rat soleus muscles indicated that the hypokalæmic
effect of salbutamol is related to stimulation of the active coupled transport of sodium and
potassium in muscle cells. Follow-up studies proved that the inhalation of salbutamol is a
simple and adequate method for the treatment of the paralytic episodes in these patients.
alleviated hyperkalæmia and paralysis precipitated by exercise or oral administration of
potassium chloride. In-vitro studies with rat soleus muscles indicated that the hypokalæmic
effect of salbutamol is related to stimulation of the active coupled transport of sodium and
potassium in muscle cells. Follow-up studies proved that the inhalation of salbutamol is a
simple and adequate method for the treatment of the paralytic episodes in these patients.
Abstract
In fifteen patients with hyperkalæmic familial periodic paralysis, inhalation of salbutamol alleviated hyperkalæmia and paralysis precipitated by exercise or oral administration of potassium chloride. In-vitro studies with rat soleus muscles indicated that the hypokalæmic effect of salbutamol is related to stimulation of the active coupled transport of sodium and potassium in muscle cells. Follow-up studies proved that the inhalation of salbutamol is a simple and adequate method for the treatment of the paralytic episodes in these patients.
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