High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors
MJ Barnes, K Lapanowski, A Conley, JA Rafols… - Brain research …, 2003 - Elsevier
Obesity and high fat diets are associated with an increased prevalence of diabetes,
cardiovascular disease, and hypertension. However, the mechanism (s) linking obesity and
high fat diet to these metabolic and cardiovascular disorders are not fully elucidated. Leptin
stimulates the formation of pro-opiomelanocortin and its products. The stimulation of the
central nervous system (CNS) opioids and their receptors is associated with an increase in
cardiovascular dynamics. In this study we hypothesized that obesity changed the CNS …
cardiovascular disease, and hypertension. However, the mechanism (s) linking obesity and
high fat diet to these metabolic and cardiovascular disorders are not fully elucidated. Leptin
stimulates the formation of pro-opiomelanocortin and its products. The stimulation of the
central nervous system (CNS) opioids and their receptors is associated with an increase in
cardiovascular dynamics. In this study we hypothesized that obesity changed the CNS …