Activation of the transcription factor ISGF3 by interferon-gamma
M Matsumoto, N Tanaka, H Harada, T Kimura… - 1999 - degruyter.com
M Matsumoto, N Tanaka, H Harada, T Kimura, T Yokochi, M Kitagawa, C Schindler…
1999•degruyter.comThe interferon-stimulated gene factor 3 (ISGF3) transcription factor has been extensively
studied in the context of the type I interferon (IFN-α/β)-mediated antiviral response; it consists
of the major DNA-binding component p48, and the signal transducers and activators of
transcription (Stat) 1 and Stat2. We show here that type II IFN (IFN-γ) can also invoke the
activation of ISGF3 in mouse primary embryonic fibroblasts. In fact, the two Stat proteins
were tyrosine phosphorylated in IFN-γ stimulated cells. Our present findings reveal an …
studied in the context of the type I interferon (IFN-α/β)-mediated antiviral response; it consists
of the major DNA-binding component p48, and the signal transducers and activators of
transcription (Stat) 1 and Stat2. We show here that type II IFN (IFN-γ) can also invoke the
activation of ISGF3 in mouse primary embryonic fibroblasts. In fact, the two Stat proteins
were tyrosine phosphorylated in IFN-γ stimulated cells. Our present findings reveal an …
Abstract
The interferon-stimulated gene factor 3 (ISGF3) transcription factor has been extensively studied in the context of the type I interferon (IFN-α/β)-mediated antiviral response; it consists of the major DNA-binding component p48, and the signal transducers and activators of transcription (Stat)1 and Stat2. We show here that type II IFN (IFN-γ) can also invoke the activation of ISGF3 in mouse primary embryonic fibroblasts. In fact, the two Stat proteins were tyrosine phosphorylated in IFN-γ stimulated cells. Our present findings reveal an additional mechanism by which these two distinct types of cytokines, IFN-α/β and -γ, can commonly elicit antiviral activities.
De Gruyter