Pathophysiologic alterations induced by tumor necrosis factor
DG Remick, SL Kunkel - International Review of Experimental Pathology, 1993 - Elsevier
Publisher Summary This chapter discusses the pathophysiologic alterations that can be
induced by tumor necrosis factor (TNF). The most sensitive parameter for detecting an effect
of TNF is the alteration in peripheral blood constituents. In a study described in the chapter,
rHuTNF is injected into mice, which results in the rapid induction of lymphopenia and
neutrophilia. The kinetics of these peripheral blood alterations are extremely rapid, with
statistically significant alterations occurring within 1 hr. The lymphopenia and neutrophilia …
induced by tumor necrosis factor (TNF). The most sensitive parameter for detecting an effect
of TNF is the alteration in peripheral blood constituents. In a study described in the chapter,
rHuTNF is injected into mice, which results in the rapid induction of lymphopenia and
neutrophilia. The kinetics of these peripheral blood alterations are extremely rapid, with
statistically significant alterations occurring within 1 hr. The lymphopenia and neutrophilia …