Membrane form of TNFα induces both cell lysis and apoptosis in susceptible target cells
G Monastra, A Cabrelle, A Zambon, A Rosato… - Cellular …, 1996 - Elsevier
Tumor necrosis factor α, in the secreted as well as membrane-associated (mTNFα) form,
represents a cytotoxic effector mechanism of activated macrophages; in contrast, direct
evidence of the mTNFα involvement in cytotoxic T lymphocyte (CTL)-mediated lysis has not
yet been obtained. We observed that following activation with anti-CD3 monoclonal antibody
(mAb), both cloned CTL and peritoneal exudate lymphocytes rapidly upregulated mTNFα; a
similar effect was observed in the macrophage cell line J774 after stimulation with …
represents a cytotoxic effector mechanism of activated macrophages; in contrast, direct
evidence of the mTNFα involvement in cytotoxic T lymphocyte (CTL)-mediated lysis has not
yet been obtained. We observed that following activation with anti-CD3 monoclonal antibody
(mAb), both cloned CTL and peritoneal exudate lymphocytes rapidly upregulated mTNFα; a
similar effect was observed in the macrophage cell line J774 after stimulation with …