HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene
KT Jeang, SG Widen, OJ Semmes 4th, SH Wilson - Science, 1990 - science.org
KT Jeang, SG Widen, OJ Semmes 4th, SH Wilson
Science, 1990•science.orgHuman T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia
(ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long
terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the
expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA
repair. This finding suggests a possible correlation between HTLV-I infection and host
chromosomal damage, which is often seen in ATL cells.
(ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long
terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the
expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA
repair. This finding suggests a possible correlation between HTLV-I infection and host
chromosomal damage, which is often seen in ATL cells.
Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.
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