[PDF][PDF] Fratricide among CD8+ T lymphocytes naturally infected with human T cell lymphotropic virus type I
E Hanon, JC Stinchcombe, M Saito, BE Asquith… - Immunity, 2000 - cell.com
E Hanon, JC Stinchcombe, M Saito, BE Asquith, GP Taylor, Y Tanaka, JN Weber…
Immunity, 2000•cell.comInfection and gene expression by the human T lymphotropic virus type I (HTLV-I) in vivo
have been thought to be confined to CD4+ T lymphocytes. We show here that, in natural
HTLV-I infection, a significant proportion of CD8+ T lymphocytes are infected by HTLV-I.
Interestingly, HTLV-I-specific but not Epstein-Barr virus–specific CD8+ T lymphocytes were
shown to be infected. Furthermore, HTLV-I protein expression in naturally infected CD8+ T
lymphocytes renders them susceptible to fratricide mediated by autologous HTLV-I-specific …
have been thought to be confined to CD4+ T lymphocytes. We show here that, in natural
HTLV-I infection, a significant proportion of CD8+ T lymphocytes are infected by HTLV-I.
Interestingly, HTLV-I-specific but not Epstein-Barr virus–specific CD8+ T lymphocytes were
shown to be infected. Furthermore, HTLV-I protein expression in naturally infected CD8+ T
lymphocytes renders them susceptible to fratricide mediated by autologous HTLV-I-specific …
Abstract
Infection and gene expression by the human T lymphotropic virus type I (HTLV-I) in vivo have been thought to be confined to CD4+ T lymphocytes. We show here that, in natural HTLV-I infection, a significant proportion of CD8+ T lymphocytes are infected by HTLV-I. Interestingly, HTLV-I-specific but not Epstein-Barr virus–specific CD8+ T lymphocytes were shown to be infected. Furthermore, HTLV-I protein expression in naturally infected CD8+ T lymphocytes renders them susceptible to fratricide mediated by autologous HTLV-I-specific CD8+ T lymphocytes. Fratricide among virus-specific CTLs could impair the immune control of HTLV-I and possibly other lymphotropic viruses.
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