Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment …
TM Ross, PM Martinez, JC Renner, RG Thorne… - Journal of …, 2004 - Elsevier
Intranasal (IN) administration of IFNβ-1b was examined as a route for targeted delivery to the
rat central nervous system (CNS). Intranasal administration resulted in significant delivery
throughout the CNS and cervical lymph nodes with low delivery to peripheral organs. At
similar blood levels, intravenous (IV) administration of IFNβ-1b yielded 88–98% lower CNS
levels and 100–1650% greater peripheral organ levels compared to intranasal.
Autoradiography confirmed much greater delivery to the CNS with intranasal administration …
rat central nervous system (CNS). Intranasal administration resulted in significant delivery
throughout the CNS and cervical lymph nodes with low delivery to peripheral organs. At
similar blood levels, intravenous (IV) administration of IFNβ-1b yielded 88–98% lower CNS
levels and 100–1650% greater peripheral organ levels compared to intranasal.
Autoradiography confirmed much greater delivery to the CNS with intranasal administration …