A2B5+ and O4+ Cycling progenitors in the adult forebrain white matter respond differentially to PDGF-AA, FGF-2, and IGF-1
JL Mason, JE Goldman - Molecular and Cellular Neuroscience, 2002 - Elsevier
Cycling glial progenitors reside within subcortical white matter of the mammalian adult
forebrain. Either A2B5 or O4 expression defines two of the major classes of cycling
progenitors. We examined the growth factor receptor profiles of these progenitor populations
and their capability to proliferate and differentiate in response to PDGF-AA, FGF-2, and IGF-
1. FGF-2 and IGF-1 enhance the acquisition of O1 by the O4+ progenitors, but have no
significant effect on the acquisition of O4 and/or O1 by the A2B5+ progenitors. In contrast …
forebrain. Either A2B5 or O4 expression defines two of the major classes of cycling
progenitors. We examined the growth factor receptor profiles of these progenitor populations
and their capability to proliferate and differentiate in response to PDGF-AA, FGF-2, and IGF-
1. FGF-2 and IGF-1 enhance the acquisition of O1 by the O4+ progenitors, but have no
significant effect on the acquisition of O4 and/or O1 by the A2B5+ progenitors. In contrast …