Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination
WW Li, A Setzu, C Zhao, RJM Franklin - Journal of neuroimmunology, 2005 - Elsevier
Minocycline, a tetracycline derivative, disrupts inflammatory processes within the CNS and
reduces demyelination in experimental autoimmune encephalomyelitis. Several recent
studies indicate that components of the inflammatory response to demyelination may be
beneficial for the regenerative process of remyelination. In this study we examined the
effects of minocycline on remyelination independent of its effects in limiting immune-
mediated white matter damage using a toxin model of demyelination. Demyelinating lesions …
reduces demyelination in experimental autoimmune encephalomyelitis. Several recent
studies indicate that components of the inflammatory response to demyelination may be
beneficial for the regenerative process of remyelination. In this study we examined the
effects of minocycline on remyelination independent of its effects in limiting immune-
mediated white matter damage using a toxin model of demyelination. Demyelinating lesions …