Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them …
O Butovsky, AE Talpalar, K Ben-Yaakov… - Molecular and Cellular …, 2005 - Elsevier
'Protective autoimmunity'refers to a well-controlled anti-self response that helps the body
resist neurodegeneration. The response is mediated by autoimmune T cells, which produce
cytokines and growth factors. Using an in vitro assay of hippocampal slices, we show that
the cytokines interferon-γ and (especially) interleukin-4, characteristic of pro-inflammatory
and anti-inflammatory T cells, respectively, can make microglia neuroprotective. Aggregated
β-amyloid, like bacterial cell wall-derived lipopolysaccharide, rendered the microglia …
resist neurodegeneration. The response is mediated by autoimmune T cells, which produce
cytokines and growth factors. Using an in vitro assay of hippocampal slices, we show that
the cytokines interferon-γ and (especially) interleukin-4, characteristic of pro-inflammatory
and anti-inflammatory T cells, respectively, can make microglia neuroprotective. Aggregated
β-amyloid, like bacterial cell wall-derived lipopolysaccharide, rendered the microglia …