Identification of MHC class II and TCR binding residues in the type II collagen immunodominant determinant mediating collagen-induced arthritis
EF Rosloniec, KB Whittington, DD Brand, LK Myers… - Cellular …, 1996 - Elsevier
Collagen-induced arthritis (CIA), an autoimmune arthritis model, is elicited by the
immunization of genetically susceptible strains of mice with type II collagen (CII). We have
analyzed the molecular interactions that occur during the presentation of the
immunodominant determinant within CII (257–270) by the murine class II susceptibility
allele, I-Aq. Utilizing a soluble IA binding assay and clonally distinct CII-specific T cells, we
have identified the residues that control the ability of the CII (257–270) peptide to bind to I …
immunization of genetically susceptible strains of mice with type II collagen (CII). We have
analyzed the molecular interactions that occur during the presentation of the
immunodominant determinant within CII (257–270) by the murine class II susceptibility
allele, I-Aq. Utilizing a soluble IA binding assay and clonally distinct CII-specific T cells, we
have identified the residues that control the ability of the CII (257–270) peptide to bind to I …
