[HTML][HTML] The orphan nuclear receptor NGFIB regulates transcription of 3β-hydroxysteroid dehydrogenase: implications for the control of adrenal functional zonation
MH Bassett, T Suzuki, H Sasano, CJM De Vries… - Journal of Biological …, 2004 - ASBMB
3β-Hydroxysteroid dehydrogenase type 2 (HSD3B2) is a steroid-metabolizing enzyme that
is essential for adrenal production of mineralocorticoids and glucocorticoids. Thus, HSD3B2
is expressed at high levels in the glomerulosa and fasciculata, where these steroids are
produced. In contrast, the production of dehydroepiandrosterone (DHEA) and DHEA sulfate
in the adrenal reticularis is inversely correlated with the expression of HSD3B2. The reasons
for the zonal expression of HSD3B2 are not known but represent an important aspect in the …
is essential for adrenal production of mineralocorticoids and glucocorticoids. Thus, HSD3B2
is expressed at high levels in the glomerulosa and fasciculata, where these steroids are
produced. In contrast, the production of dehydroepiandrosterone (DHEA) and DHEA sulfate
in the adrenal reticularis is inversely correlated with the expression of HSD3B2. The reasons
for the zonal expression of HSD3B2 are not known but represent an important aspect in the …