Immunohistochemical study of cytochrome P-45017α in human adrenocortical disorders

H Sasano, JI Mason, N Sasano - Human pathology, 1989 - Elsevier
Cytochrome P-450 specific for steroid 17α-hydroxylation (P-450 17α) was immunolocalized
in normal and hyperfunctioning adrenal glands of pigs, bovines, and humans, using a
specific IgG fraction raised against the enzyme. P-450 17α was present in the zona
fasciculata (ZF) and zona reticularis (ZR), but not in the zona glomerulosa (ZG), in pig,
bovine, and human adrenal glands. In the adrenal glands of patients with Cushing's
disease, the positive immunoreactivity to P-450 17α was intense in ZF and ZR, particularly in …