The utilization of placental substrates for cortisol synthesis by the baboon fetus near term
GJ Pepe, ED Albrecht - Steroids, 1980 - Elsevier
We have determined the proportion of the in vivo cortisol (F) secretion rate (SRF) derived
from circulating pregnenolone (P5) and progesterone (P4) in 9 baboon (Papio papio)
neonates, 5 (4♂, 1♀) delivered prior to the onset of labor by cesarean section (CS, 164–
179 days) and 4 (2♂, 2♀) delivered spontaneously at term (SD, 164–179 days; term= 184
days). The metabolic clearance rate (MCR; 1/d/kg) and production rates (PR; mg/d/kg) of P4
and P5 and transfer constants (p) for the reactions P5→ P4 14 P5→ F, and P4→ F, were …
from circulating pregnenolone (P5) and progesterone (P4) in 9 baboon (Papio papio)
neonates, 5 (4♂, 1♀) delivered prior to the onset of labor by cesarean section (CS, 164–
179 days) and 4 (2♂, 2♀) delivered spontaneously at term (SD, 164–179 days; term= 184
days). The metabolic clearance rate (MCR; 1/d/kg) and production rates (PR; mg/d/kg) of P4
and P5 and transfer constants (p) for the reactions P5→ P4 14 P5→ F, and P4→ F, were …