Tolerance and autoimmunity
T Kamradt, NA Mitchison - New England Journal of Medicine, 2001 - Mass Medical Soc
T Kamradt, NA Mitchison
New England Journal of Medicine, 2001•Mass Medical SocThe immunologic specificity of the antigen receptors of T cells and B cells is the result of
random shuffling of the many genes that form the DNA code for the antigen-binding site of
these receptors. 1–3 Theoretically, this process could generate 109 different T-cell
receptors, including some that can bind to autoantigens (these cells are often called self-
reactive T cells). Tolerance is the process that eliminates or neutralizes such autoreactive
cells, and a breakdown in the working of this system can cause autoimmunity. B-Cell …
random shuffling of the many genes that form the DNA code for the antigen-binding site of
these receptors. 1–3 Theoretically, this process could generate 109 different T-cell
receptors, including some that can bind to autoantigens (these cells are often called self-
reactive T cells). Tolerance is the process that eliminates or neutralizes such autoreactive
cells, and a breakdown in the working of this system can cause autoimmunity. B-Cell …
The immunologic specificity of the antigen receptors of T cells and B cells is the result of random shuffling of the many genes that form the DNA code for the antigen-binding site of these receptors.1–3 Theoretically, this process could generate 109 different T-cell receptors, including some that can bind to autoantigens (these cells are often called self-reactive T cells). Tolerance is the process that eliminates or neutralizes such autoreactive cells, and a breakdown in the working of this system can cause autoimmunity.
B-Cell Tolerance
Autoantibodies are characteristic of many autoimmune diseases and may be the direct cause of the . . .
The New England Journal Of Medicine