[HTML][HTML] Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB

B Hartenstein, S Teurich, J Hess, J Schenkel… - The EMBO …, 2002 - embopress.org
B Hartenstein, S Teurich, J Hess, J Schenkel, M Schorpp-Kistner, P Angel
The EMBO journal, 2002embopress.org
Naļve CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are
classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro
polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-
5. These cells produce IFN-γ and express T-bet, the key regulator of Th1 cells. In line with
the essential role of Th2 cells in the pathogenesis of allergic asthma, mice with JunB-
deficient CD4+ T cells exhibited an impaired allergen-induced airway inflammation. This …
Naļve CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-5. These cells produce IFN-γ and express T-bet, the key regulator of Th1 cells. In line with the essential role of Th2 cells in the pathogenesis of allergic asthma, mice with JunB-deficient CD4+ T cells exhibited an impaired allergen-induced airway inflammation. This study demonstrates novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2-dependent immune response in mice.
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