[HTML][HTML] LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-α-mediated human primary hepatocyte apoptosis, but not Fas …
H Matsui, Y Hikichi, I Tsuji, T Yamada… - Journal of Biological …, 2002 - ASBMB
LIGHT is a member of tumor necrosis factor (TNF) superfamily, and its receptors have been
identified as lymphotoxin-β receptor (LTβR) and the herpesvirus entry mediator
(HVEM)/ATAR/TR2, both of which lack the cytoplasmic sequence termed the" death
domain." The present study has demonstrated that LIGHT inhibits TNFα-mediated apoptosis
of human primary hepatocytes sensitized by actinomycin D (ActD), but not Fas-or TRAIL-
mediated apoptosis. Furthermore, LIGHT does not prevent some cell lines such as HepG2 or …
identified as lymphotoxin-β receptor (LTβR) and the herpesvirus entry mediator
(HVEM)/ATAR/TR2, both of which lack the cytoplasmic sequence termed the" death
domain." The present study has demonstrated that LIGHT inhibits TNFα-mediated apoptosis
of human primary hepatocytes sensitized by actinomycin D (ActD), but not Fas-or TRAIL-
mediated apoptosis. Furthermore, LIGHT does not prevent some cell lines such as HepG2 or …