[HTML][HTML] α1-Adrenergic Receptor Subtype mRNAs Are Differentially Regulated by α1-Adrenergic and Other Hypertrophic Stimuli in Cardiac Myocytes in Culture and In …
DG Rokosh, AFR Stewart, KC Chang, BA Bailey… - Journal of Biological …, 1996 - ASBMB
The three cloned α 1-adrenergic receptor (AR) subtypes, α 1B, α 1C, and α 1D, can all
couple to the same effector, phospholipase C, and the reason (s) for conservation of multiple
subtypes remain uncertain. All three α 1-ARs are expressed natively in cultured neonatal rat
cardiac myocytes, where chronic exposure to the agonist catecholamine norepinephrine
(NE) induces hypertrophic growth and gene transcription. We show here, using RNase
protection, that the α 1-AR subtype mRNAs respond in distinctly different ways during …
couple to the same effector, phospholipase C, and the reason (s) for conservation of multiple
subtypes remain uncertain. All three α 1-ARs are expressed natively in cultured neonatal rat
cardiac myocytes, where chronic exposure to the agonist catecholamine norepinephrine
(NE) induces hypertrophic growth and gene transcription. We show here, using RNase
protection, that the α 1-AR subtype mRNAs respond in distinctly different ways during …