Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support
A Rodrigue-Way, D Burkhoff, BJ Geesaman… - The Journal of heart and …, 2005 - Elsevier
BACKGROUND: Left ventricular assist devices (LVADs) implanted in patients with severe
congestive heart failure (CHF) as a bridge to transplantation have been shown to reverse
chamber enlargement, regress cellular hypertrophy, and increase contractility. The purpose
of this study was to gain a better understanding of the molecular changes associated with
increased contractility after LVAD support. METHODS: We took tissue sections from the left
ventricular apex of 12 patients with CHF who were undergoing LVAD insertion (pre-LVAD) …
congestive heart failure (CHF) as a bridge to transplantation have been shown to reverse
chamber enlargement, regress cellular hypertrophy, and increase contractility. The purpose
of this study was to gain a better understanding of the molecular changes associated with
increased contractility after LVAD support. METHODS: We took tissue sections from the left
ventricular apex of 12 patients with CHF who were undergoing LVAD insertion (pre-LVAD) …