Alzheimer's disease is a synaptic failure
DJ Selkoe - Science, 2002 - science.org
Science, 2002•science.org
In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably
pure impairment of memory. Mounting evidence suggests that this syndrome begins with
subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and
that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β
protein.
pure impairment of memory. Mounting evidence suggests that this syndrome begins with
subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and
that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β
protein.
In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
AAAS