Correlation between Aβx-40–, Aβx-42–, and Aβx-43–containing amyloid plaques and cognitive decline
S Parvathy, P Davies, V Haroutunian… - Archives of …, 2001 - jamanetwork.com
Context Accumulation of senile plaques containing amyloid β (Aβ)-protein is a pathologic
hallmark of Alzheimer disease. Amyloid β-peptide is heterogeneous, with carboxyterminal
variants ending at residues Val40 (Aβx-40), Ala42 (Aβx-42), or Thr43 (Aβx-43). The relative
importance of each of these variants in dementia or cognitive decline remains unclear.
Objective To study whether Aβ deposition correlates with dementia and occurs at the earliest
signs of cognitive decline. Design, Setting, and Patients Postmortem cross-sectional study …
hallmark of Alzheimer disease. Amyloid β-peptide is heterogeneous, with carboxyterminal
variants ending at residues Val40 (Aβx-40), Ala42 (Aβx-42), or Thr43 (Aβx-43). The relative
importance of each of these variants in dementia or cognitive decline remains unclear.
Objective To study whether Aβ deposition correlates with dementia and occurs at the earliest
signs of cognitive decline. Design, Setting, and Patients Postmortem cross-sectional study …