Taking our breath away: dendritic cells in the pathogenesis of asthma
BN Lambrecht, H Hammad - Nature Reviews Immunology, 2003 - nature.com
BN Lambrecht, H Hammad
Nature Reviews Immunology, 2003•nature.comDendritic cells (DCs) are mainly known for their capacity to induce primary immune
responses. Here, we propose that DCs are similarly essential for controlling effector T-cell
responses and, therefore, might have a role in T-cell-mediated diseases. In the case of
asthma, airway DCs are essential for controlling T helper 2 (TH 2)-dependent eosinophilic
airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
responses. Here, we propose that DCs are similarly essential for controlling effector T-cell
responses and, therefore, might have a role in T-cell-mediated diseases. In the case of
asthma, airway DCs are essential for controlling T helper 2 (TH 2)-dependent eosinophilic
airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
Abstract
Dendritic cells (DCs) are mainly known for their capacity to induce primary immune responses. Here, we propose that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T-cell-mediated diseases. In the case of asthma, airway DCs are essential for controlling T helper 2 (T H 2)-dependent eosinophilic airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
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