Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease
K Maruo, T Akaike, T Ono, T Okamoto… - Journal of allergy and …, 1997 - Elsevier
Background: The group 3 allergen of Dermatophagoides species (Der p 3 and Der f 3) has
been identified as a 30 kd trypsin-like protease of the house dust mite. We previously
showed that the 30 kd protease from Dermatophagoides farinae (Df-protease) could activate
the bradykinin-generating cascade and exacerbate inflammatory reactions. Objective: The
purpose of this study was to determine whether Df-protease could enzymatically generate
anaphylatoxins from complement components C3 and C5. Methods: Df-protease was …
been identified as a 30 kd trypsin-like protease of the house dust mite. We previously
showed that the 30 kd protease from Dermatophagoides farinae (Df-protease) could activate
the bradykinin-generating cascade and exacerbate inflammatory reactions. Objective: The
purpose of this study was to determine whether Df-protease could enzymatically generate
anaphylatoxins from complement components C3 and C5. Methods: Df-protease was …