Preovulatory treatment of mice with anti-VEGF receptor 2 antibody inhibits angiogenesis in corpora lutea
RC Zimmermann, T Hartman, P Bohlen, MV Sauer… - Microvascular …, 2001 - Elsevier
Adult mammalian angiogenesis occurs predominantly in female reproductive organs: the
ovary and the uterus. Angiogenesis is very active during corpus luteum formation. A key
regulator of angiogenesis is vascular endothelial growth factor (VEGF), which is highly
expressed during corpus luteum formation. Inhibition of VEGF activity can block the
formation and function of the corpora lutea by preventing angiogenesis. The VEGF receptor
2 (VEGF-R2) mediates the angiogenic action of VEGF and is expressed during corpus …
ovary and the uterus. Angiogenesis is very active during corpus luteum formation. A key
regulator of angiogenesis is vascular endothelial growth factor (VEGF), which is highly
expressed during corpus luteum formation. Inhibition of VEGF activity can block the
formation and function of the corpora lutea by preventing angiogenesis. The VEGF receptor
2 (VEGF-R2) mediates the angiogenic action of VEGF and is expressed during corpus …