[HTML][HTML] Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
A Garcia-Ocana, KK Takane, MA Syed… - Journal of Biological …, 2000 - ASBMB
Hepatocyte growth factor (HGF) is produced in pancreatic mesenchyme-derived cells and in
islet cells. In vitro, HGF increases the insulin content and proliferation of islets. To study the
role of HGF in the islet in vivo, we have developed three lines of transgenic mice
overexpressing mHGF using the rat insulin II promoter (RIP). Each RIP-HGF transgenic line
displays clear expression of HGF mRNA and protein in the islet. RIP-mHGF mice are
relatively hypoglycemic in post-prandial and fasting states compared with their normal …
islet cells. In vitro, HGF increases the insulin content and proliferation of islets. To study the
role of HGF in the islet in vivo, we have developed three lines of transgenic mice
overexpressing mHGF using the rat insulin II promoter (RIP). Each RIP-HGF transgenic line
displays clear expression of HGF mRNA and protein in the islet. RIP-mHGF mice are
relatively hypoglycemic in post-prandial and fasting states compared with their normal …