Targeting RAS signalling pathways in cancer therapy
J Downward - Nature reviews cancer, 2003 - nature.com
Nature reviews cancer, 2003•nature.com
The RAS proteins control signalling pathways that are key regulators of several aspects of
normal cell growth and malignant transformation. They are aberrant in most human tumours
due to activating mutations in the RAS genes themselves or to alterations in upstream or
downstream signalling components. Rational therapies that target the RAS pathways might
inhibit tumour growth, survival and spread. Several of these new therapeutic agents are
showing promise in the clinic and many more are being developed.
normal cell growth and malignant transformation. They are aberrant in most human tumours
due to activating mutations in the RAS genes themselves or to alterations in upstream or
downstream signalling components. Rational therapies that target the RAS pathways might
inhibit tumour growth, survival and spread. Several of these new therapeutic agents are
showing promise in the clinic and many more are being developed.
Abstract
The RAS proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. They are aberrant in most human tumours due to activating mutations in the RAS genes themselves or to alterations in upstream or downstream signalling components. Rational therapies that target the RAS pathways might inhibit tumour growth, survival and spread. Several of these new therapeutic agents are showing promise in the clinic and many more are being developed.
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