[HTML][HTML] The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation
JP Chapple, ME Cheetham - Journal of Biological Chemistry, 2003 - ASBMB
The human DnaJ (Hsp40) proteins HSJ1a and HSJ1b are type II DnaJ proteins with different
C termini generated by alternate splicing. Both protein isoforms can regulate the ATPase
activity and substrate binding of Hsp70. In this study, we have confirmed the neuronal
expression of HSJ1a and HSJ1b proteins and localized their expression in human neural
retina using isoform-specific antisera. HSJ1a and HSJ1b were enriched in photoreceptors,
particularly the inner segments, but had different intracellular localization due to the …
C termini generated by alternate splicing. Both protein isoforms can regulate the ATPase
activity and substrate binding of Hsp70. In this study, we have confirmed the neuronal
expression of HSJ1a and HSJ1b proteins and localized their expression in human neural
retina using isoform-specific antisera. HSJ1a and HSJ1b were enriched in photoreceptors,
particularly the inner segments, but had different intracellular localization due to the …