[HTML][HTML] GATA-4 activates transcription via two novel domains that are conserved within the GATA-4/5/6 subfamily
EE Morrisey, HS Ip, Z Tang, MS Parmacek - Journal of Biological Chemistry, 1997 - ASBMB
GATA-4 is one of the earliest developmental markers of the precardiac mesoderm, heart,
and gut and has been shown to activate regulatory elements controlling transcription of
genes encoding cardiac-specific proteins. To elucidate the molecular mechanisms
underlying the transcriptional activity of the GATA-4 protein, structure-function analyses were
performed. These analyses revealed that the C-terminal zinc finger and adjacent basic
domain of GATA-4 is bifunctional, modulating both DNA-binding and nuclear localization …
and gut and has been shown to activate regulatory elements controlling transcription of
genes encoding cardiac-specific proteins. To elucidate the molecular mechanisms
underlying the transcriptional activity of the GATA-4 protein, structure-function analyses were
performed. These analyses revealed that the C-terminal zinc finger and adjacent basic
domain of GATA-4 is bifunctional, modulating both DNA-binding and nuclear localization …