[HTML][HTML] The bell-shaped Ca2+ dependence of the inositol 1, 4, 5-trisphosphate-induced Ca2+ release is modulated by Ca2+/calmodulin
L Missiaen, JB Parys, AF Weidema, H Sipma… - Journal of Biological …, 1999 - ASBMB
Calmodulin inhibits inositol 1, 4, 5-trisphosphate (IP 3) binding to the IP 3 receptor in both a
Ca 2+-dependent and a Ca 2+-independent way. Because there are no functional data on
the modulation of the IP 3-induced Ca 2+ release by calmodulin at various Ca 2+
concentrations, we have studied how cytosolic Ca 2+ and Sr 2+ interfere with the effects of
calmodulin on the IP 3-induced Ca 2+ release in permeabilized A7r5 cells. We now report
that calmodulin inhibited Ca 2+ release through the IP 3 receptor with an IC 50 of 4.6 μm if …
Ca 2+-dependent and a Ca 2+-independent way. Because there are no functional data on
the modulation of the IP 3-induced Ca 2+ release by calmodulin at various Ca 2+
concentrations, we have studied how cytosolic Ca 2+ and Sr 2+ interfere with the effects of
calmodulin on the IP 3-induced Ca 2+ release in permeabilized A7r5 cells. We now report
that calmodulin inhibited Ca 2+ release through the IP 3 receptor with an IC 50 of 4.6 μm if …
