[HTML][HTML] Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor α, and oncostatin M receptor β by distinct mechanisms
F Blanchard, Y Wang, E Kinzie, L Duplomb… - Journal of Biological …, 2001 - ASBMB
The cytokine receptor subunits gp130, leukemia inhibitory factor receptor α (LIFRα), and
oncostatin M receptor β (OSMRβ) transduce OSM signals that regulate gene expression and
cell proliferation. After ligand binding and activation of the Janus protein-tyrosine
kinase/STAT and mitogen-activated protein kinase signal transduction pathways, negative
feedback processes are recruited. These processes attenuate receptor action by
suppression of cytokine signaling and by down-regulation of receptor protein expression …
oncostatin M receptor β (OSMRβ) transduce OSM signals that regulate gene expression and
cell proliferation. After ligand binding and activation of the Janus protein-tyrosine
kinase/STAT and mitogen-activated protein kinase signal transduction pathways, negative
feedback processes are recruited. These processes attenuate receptor action by
suppression of cytokine signaling and by down-regulation of receptor protein expression …