[HTML][HTML] The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor
JM Mason, BK Beattie, Q Liu, DJ Dumont… - Journal of Biological …, 2000 - ASBMB
Ship1 (SH2 inositol 5-phosphatase 1) has been shown to be a target of tyrosine
phosphorylation downstream of cytokine and immunoregulatory receptors. In addition to its
catalytic activity on phosphatidylinositol substrates, it can serve as an adaptor protein in
binding Shc and Grb2. Erythropoietin (EPO), the primary regulator of erythropoiesis, has
been shown to activate the tyrosine phosphorylation of Shc, resulting in recruitment of Grb2.
However, the mechanism by which the erythropoietin receptor (EPO-R) recruits Shc remains …
phosphorylation downstream of cytokine and immunoregulatory receptors. In addition to its
catalytic activity on phosphatidylinositol substrates, it can serve as an adaptor protein in
binding Shc and Grb2. Erythropoietin (EPO), the primary regulator of erythropoiesis, has
been shown to activate the tyrosine phosphorylation of Shc, resulting in recruitment of Grb2.
However, the mechanism by which the erythropoietin receptor (EPO-R) recruits Shc remains …