Delayed liver regeneration in peroxisome proliferator-activated receptor-α-null mice
SP Anderson, L Yoon, EB Richard, CS Dunn… - Hepatology, 2002 - Elsevier
Peroxisome proliferator chemicals, acting via the peroxisome proliferator-activated receptor-
α (Pparα), are potent hepatic mitogens and carcinogens in mice and rats. To test whether
Pparα is required for hepatic growth in response to other stimuli, we studied liver
regeneration and hepatic gene expression following partial hepatectomy (PH) of wild-type
and Pparα-null mice. Pparα-null mice had a 12-to 24-hour delay in liver regeneration
associated with a delayed onset and lower peak magnitude of hepatocellular DNA …
α (Pparα), are potent hepatic mitogens and carcinogens in mice and rats. To test whether
Pparα is required for hepatic growth in response to other stimuli, we studied liver
regeneration and hepatic gene expression following partial hepatectomy (PH) of wild-type
and Pparα-null mice. Pparα-null mice had a 12-to 24-hour delay in liver regeneration
associated with a delayed onset and lower peak magnitude of hepatocellular DNA …