[HTML][HTML] Peroxisome proliferator-activated receptor γ induces a phenotypic switch from activated to quiescent hepatic stellate cells

S Hazra, S Xiong, J Wang, RA Rippe, V Krishna… - Journal of Biological …, 2004 - ASBMB
Depletion of peroxisome proliferator-activated receptor γ (PPARγ) accompanies
myofibroblastic transdifferentiation of hepatic stellate cells (HSC), the primary cellular event
underlying liver fibrogenesis. The treatment of activated HSC in vitro or in vivo with synthetic
PPARγ ligands suppresses the fibrogenic activity of HSC. However, it is uncertain whether
PPARγ is indeed a molecular target of this effect, because the ligands are also known to
have receptor-independent actions. To test this question, the present study examined the …