Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury
S Cuzzocrea - Vascular pharmacology, 2004 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors that are related to retinoid,
steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members,
PPAR-α, PPAR-β and PPAR-γ. PPAR-γ has recently been implicated as a regulator of
cellular proliferation and inflammatory responses. There is good evidence that ligands of
PPAR-γ, including certain thiazolinediones, reduce tissue injury associated with ischemia …
receptor superfamily of ligand-activated transcription factors that are related to retinoid,
steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members,
PPAR-α, PPAR-β and PPAR-γ. PPAR-γ has recently been implicated as a regulator of
cellular proliferation and inflammatory responses. There is good evidence that ligands of
PPAR-γ, including certain thiazolinediones, reduce tissue injury associated with ischemia …