Correlation of Expression of Cyclooxygenase-2, Vascular Endothelial Growth Factor, and Peroxisome Proliferator–Activated Receptor δ With Head and Neck …
EC Jaeckel, S Raja, J Tan, SK Das… - … –Head & Neck …, 2001 - jamanetwork.com
Cyclooxygenase (COX) is the rate-limiting enzyme in the formation of prostaglandins from
arachidonic acid. COX exists in 2 isoforms, COX-1 and COX-2. These isoforms are encoded
by separate genes and demonstrate cell-specific expression and regulation. Peroxisome
proliferator–activated receptor δ (PPARδ) is a nuclear transcription factor that is activated by
prostacyclin. Vascular endothelial growth factor (VEGF) is a proangiogenic factor that is up-
regulated in various tumors. Vascular endothelial growth factor has been shown to interact …
arachidonic acid. COX exists in 2 isoforms, COX-1 and COX-2. These isoforms are encoded
by separate genes and demonstrate cell-specific expression and regulation. Peroxisome
proliferator–activated receptor δ (PPARδ) is a nuclear transcription factor that is activated by
prostacyclin. Vascular endothelial growth factor (VEGF) is a proangiogenic factor that is up-
regulated in various tumors. Vascular endothelial growth factor has been shown to interact …