[HTML][HTML] Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo
X Xin, S Yang, J Kowalski, ME Gerritsen - Journal of Biological Chemistry, 1999 - ASBMB
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that functions as
a transcription factor to mediate ligand-dependent transcriptional regulation. Activation of
PPARγ by the naturally occurring ligand, 15-deoxy-Δ12, 14-prostaglandin J 2 (15d-PGJ 2),
or members of a new class of oral antidiabetic agents, eg BRL49653 and ciglitizone, has
been linked to adipocyte differentiation, regulation of glucose homeostasis, inhibition of
macrophage and monocyte activation, and inhibition of tumor cell proliferation. Here we …
a transcription factor to mediate ligand-dependent transcriptional regulation. Activation of
PPARγ by the naturally occurring ligand, 15-deoxy-Δ12, 14-prostaglandin J 2 (15d-PGJ 2),
or members of a new class of oral antidiabetic agents, eg BRL49653 and ciglitizone, has
been linked to adipocyte differentiation, regulation of glucose homeostasis, inhibition of
macrophage and monocyte activation, and inhibition of tumor cell proliferation. Here we …