Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-γ ligand
MA Sarayba, L Li, T Tungsiripat, NH Liu… - Experimental eye …, 2005 - Elsevier
Purpose. To determine the efficacy of the peroxisome proliferator-activated receptor γ
agonist, pioglitazone, in inhibiting corneal neovascularization. Methods. Twenty-six adult
male Sprague-Dawley rats were randomly divided into three groups. Each group received
intrastromal polymer micropellets containing one of the following: Group 1, no active
ingredient (n= 10); Group 2, vascular endothelial growth factor (VEGF)(n= 7); Group 3, VEGF
and pioglitazone (n= 9). Neovascularization was evaluated 7 days after pellet implantation …
agonist, pioglitazone, in inhibiting corneal neovascularization. Methods. Twenty-six adult
male Sprague-Dawley rats were randomly divided into three groups. Each group received
intrastromal polymer micropellets containing one of the following: Group 1, no active
ingredient (n= 10); Group 2, vascular endothelial growth factor (VEGF)(n= 7); Group 3, VEGF
and pioglitazone (n= 9). Neovascularization was evaluated 7 days after pellet implantation …