Peroxisome-proliferator-activated receptors and cancers: complex stories
L Michalik, B Desvergne, W Wahli - Nature Reviews Cancer, 2004 - nature.com
L Michalik, B Desvergne, W Wahli
Nature Reviews Cancer, 2004•nature.comPeroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors that
mediate the effects of fatty acids and their derivatives at the transcriptional level. Through
these pathways, PPARs can regulate cell proliferation, differentiation and survival, so
controlling carcinogenesis in various tissues. But what are the links between each PPAR
isotype and carcinogenesis and what is the relevance of these findings to human pathology
and therapy?
mediate the effects of fatty acids and their derivatives at the transcriptional level. Through
these pathways, PPARs can regulate cell proliferation, differentiation and survival, so
controlling carcinogenesis in various tissues. But what are the links between each PPAR
isotype and carcinogenesis and what is the relevance of these findings to human pathology
and therapy?
Abstract
Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. Through these pathways, PPARs can regulate cell proliferation, differentiation and survival, so controlling carcinogenesis in various tissues. But what are the links between each PPAR isotype and carcinogenesis and what is the relevance of these findings to human pathology and therapy?
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