7, 12-DMBA-induced rat leukemia: a review with insights into future research

T Sugiyama, M Osaka, K Koami, S Maeda, N Ueda - Leukemia research, 2002 - Elsevier
7, 12-Dimethylbenz [a] anthracene (DMBA) elicits leukemia in Long–Evans rats (LE). This
leukemia is mostly erythroblastic and 30% of leukemias have total and partial trisomy of# 2
chromosome and the rest have diploid karyotype. The common duplication site is in 2q26–
q34 and N-ras gene is located in 2q34. 7, 8, 12-Trimethylbenz [a] anthracene (TMBA) also
induces similar leukemias. These leukemias reveal a highly specific mutation of N-ras gene
as in human leukemias. N-ras mutation is induced 48h after DMBA treatment. Wild type N …