Molecular monitoring of BCR–ABL as a guide to clinical management in chronic myeloid leukaemia

T Hughes, S Branford - Blood reviews, 2006 - Elsevier
Molecular monitoring of BCR–ABL transcript levels by real-time quantitative PCR is
increasingly used to assess treatment response in patients with chronic myeloid leukaemia
(CML). This has become particularly relevant in the era of imatinib therapy when residual
levels of leukaemia usually fall below the level of detection by bone marrow cytogenetic
analysis. Studies of imatinib-treated patients have determined that BCR–ABL levels
measured early in therapy can predict subsequent response and the probability of acquired …